Our research is focused on severe mental disorders, including bipolar disorder and schizophrenia, with emphasis on neural development. In specific we are interested in how disturbances in the development of neural networks lead to manifest psychiatric illness. One focus is on the calcium channel gene CACNA1C, earlier implied in both disorders in previous GWAS. At the moment, we are developing IPS cell-based models of bipolar patients in conjunction with clinical data from patients.
In parallel, we pursue register based studies on clinical aspects on bipolar disorder in collaboration with professor Mikael Landén. We aim at combining deeply phenotyping patients based on clinical information in order to stratify patients for IPS cell-based modeling, using both 2D cultures and cerebral organoids.
Please see publications for more detailed information on previous work.